Traducción del artículo de resumen de un estudio de investigación sobre el efecto de diferentes fórmulas de micronutrientes en la salud ósea, y en particular, en la regeneración del tejido óseo.

Referencias

1. Roudsari JM, Mahjoub S. Quantification and comparison of bone-specific alkaline phosphatase with two methods in normal and paget’s specimens.  Caspian J Intern Med. 2012; 3(3): 478–483.
2. Elice F, Zangari M, Barlogie B, et al. Serum concentrations of vitamin B-12 and alkaline phospha tase in newly diagnosed multiple myeloma patients. Blood. 2005; 106(11): 5110. 
3. Kim GS, Kim CH, Park JY, Lee KU, Park CS. Effects of vitamin B12 on cell proliferation and cellular alkaline phosphatase activity in human bone marrow stromal  osteoprogenitor cells and UMR106 osteoblastic cells.  Metabolism. 1996; 45(12):1443-6.
4. Cho YE, Lomeda RAR, Ryu SH, et al. Zinc deficiency negatively affects alkaline phosphatase and the concentration of Ca, Mg and P in rats. Nutr Res Prac.  2007; 1(2): 113–119. doi:10.4162/nrp.2007.1.2.113.
5. Kanazawa l, Yamaguchi T, Yamamoto M, et al. Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type  2 diabetes mellitus. J Clin Endocrinol Metab. 2009;  94(1): 45-49.
6. Shi
7. Vanderschueren D, Gevers G, Raymaekers G, Devos P, Dequeker J. Sex- and age-related changes in bone and serum osteocalcin. Calcif Tissue Int. 1990; 46(3):  179-182.
8. Lewiecki EM. Role of sclerostin in bone and cartilage and its potential as a therapeutic target in bone diseases. Ther Adv Musculoskel Dis. 2014; 6(2): 48- 57. doi: 10.1177/1759720X13510479.
9. Li X, Ominsky MS, Warmington KS, et al. Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of  postmenopausal osteoporosis. J Bone Miner Res.  2009; 24(4): 578-588.
10. Miller PD, Wagman RB, Peacock M, et al. Effect of denosumab on bone mineral density and biochemical markers of bone turnover: six-year results of a phase  2 clinical trial. J Clin Endocrinol Metab. 2011; 96(2):  394-402. doi: 10.1210/jc.2010-1805.
11. Ardawi MS, Al-Kadi HA, Rouzi AA, Qari MH. Determinants of serum sclerostin in healthy pre and postmenopausal women. J Bone Miner Res. 2011; 26(12): 2812-2822. doi: 10.1002/jbmr.479.
12. Jamdar J, Rao B, Netke S, et al. (2004) Reduction in tibial shaft fracture healing time with essential nutrient supplementation containing ascorbic acid,  lysine, and proline. J Altern Complement Med. 2004;  10(6): 915-916.

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